The differences between monkeypox and chickenpox are different viral infections, different symptoms and different prognoses. 1. Different viral infection: Monkeypox is a disease caused by monkeypox virus infection, and it is also a kind of zoonosis, that is to say, some animals and human beings may be infected with monkeypox virus. The causative agent of chickenpox is “varicella zoster virus”, which belongs to herpesvirus family, and human is the only host of this virus. 2. Symptoms: Symptoms of monkeypox include fever, headache, muscle aches, back pain, swollen glands, chills and fatigue, and a rash may appear within 1 to 5 days of the first symptoms. Chickenpox symptoms include high fever, aches and pains, difficulty eating or loss of appetite, and an itchy rash that tends to blister and dry out. 3. Prognosis is different, monkeypox is a self-limiting disease, most of the patients in 2 to 4 weeks to heal themselves, some patients with serious conditions, the occurrence of collapse and death. Chickenpox patients have a good prognosis, the course of the disease in about 2 weeks, but immunodeficiency patients, or infants and young children may suffer from more serious chickenpox, there is a certain mortality rate. If the patient has monkeypox or chickenpox, it is recommended to go to the hospital in time to take appropriate isolation measures, and actively cooperate with the doctor for treatment.