Hepatitis B vaccine is given in three injections, generally according to three injections from 0-1-6 months, with the second injection 1 month after the first injection and the third injection 6 months later. Hepatitis B is a common infectious disease in China. To prevent hepatitis B, hepatitis B vaccination should be given in a timely manner, and it is only after the three vaccinations that the body may produce protective antibodies against the hepatitis B virus. Half a month after the end of the full course of injections, it is recommended to go to the hospital to check whether protective antibodies are produced and the level of antibodies to assess whether hepatitis B virus transmission can be effectively prevented by checking the hepatitis B antibodies and the quantification of the five hepatitis B items. If antibodies are produced, a booster injection can be given after 4 years, and the protective antibodies and antibody levels can be rechecked in the later 7-10 years to allow for timely booster injections. In addition, if patients develop fever and rash after hepatitis B vaccination, they should go to the hospital for examination and treatment in a timely manner, and pay attention to a light diet to avoid other diseases.