A small amount of tissue fluid is still coming out after the tube is removed for thyroid surgery and does not need to be treated. If there is a large amount of localized tissue fluid coming out, reintubation or puncture drainage may be necessary. If the patient develops a purulent effusion, treatment with antibiotics as prescribed by the doctor is needed. If there is a small amount of localized tissue fluid outflow after extubation for thyroid surgery, it may be normal and does not require special measures for treatment. This is because the localized tissue fluid will be absorbed by itself. If there is a large amount of localized tissue fluid after thyroid surgery extubation, it is necessary to perform intubation again to drain the accumulated fluid or to perform puncture drainage. In addition, if the localized purulent effusion is caused by wound infection, the patient needs to take antibiotics such as cefixime and amoxicillin under the doctor’s guidance. It is recommended that after the patient’s post-thyroid surgery extubation, the appearance of tissue fluid needs to promptly consult a doctor, the doctor will take appropriate measures to treat the patient’s condition. In addition, patients who have had thyroid surgery need to go to the hospital regularly for review, to keep the wound area clean and dry to avoid infection.