Indications for guided coitus, artificial insemination and in vitro fertilization: guided coitus and artificial insemination belong to in vivo fertilization, while in vitro fertilization belongs to in vitro fertilization. 1. Conditions for guided coitus: at least one fallopian tube is open and free of adhesion, and the husband’s semen is normal. Cervical scoring and post-coital tests are performed during natural or ovulation induction cycles when the follicles are ripe to see if this aspect of the cervix affects pregnancy. The pregnancy rate is about 10-15% per month and the natural human pregnancy rate is also 15% per month. The monthly cost is about 1,000 dollars. 2, IUI conditions: polycystic ovaries, the male partner 2 times abnormal semen liquefaction, or mild or moderate oligozoospermia; sexual dysfunction on one side; female cervical mucus score of 2 months less than 10; 3 cycles of guided coitus failed to conceive; there is a mild endometriosis; at least one side of the fallopian tubes are open. An IUI is usually done one day before and one day after ovulation, and the fee is about$6,000 a month. It is necessary to prepare an annually examined family planning certificate, ID cards of both parties, marriage certificate, and set up a specialty file. The pregnancy rate is about 15-20% per month. 3, test tube baby conditions: both sides of the fallopian tubes are imperfect or blocked, severe endometriosis, severe oligozoospermia, 3 cycles of artificial insemination failed to conceive, ovarian hypogonadism. Monthly cost is about 30,000 RMB and pregnancy rate is about 50% per month. Polycystic ovary syndrome, come to IUI. Polycystic ovary syndrome is prone to ovulation-promoting multiple follicle growth, and if at the time of doing guided coitus if multiple follicles are growing, only the cycle can be canceled and coitus is prohibited for this cycle. If if multiple follicles grow when doing IUI, you can immediately switch to IVF and match to embryos for multiple cycles of transfer, i.e., small cost, big gain.