What are the studies on early enteral nutrition

  In recent years, perioperative nutritional support for surgical patients has received increasing attention, especially early enteral nutritional support, which has received widespread attention. 193 cases of early enteral nutritional support for gastrectomy patients in our hospital from 2000 to June 2003 were summarized and reported as follows.  Clinical data 1. General data There were 193 cases in the group, 121 males and 72 females, aged from 16 to 72 years old, with an average age of 43.5 years old, clinical diagnosis, 32 cases of benign gastric ulcer, including 28 cases with acute perforation, and 162 cases of gastric cancer. Surgical methods: 33 cases of total or proximal gastrectomy, 91 cases of radical gastric cancer, 38 cases of palliative gastrectomy, and 31 cases of distal gastrectomy.  2.Placement method All cases were preoperatively placed in the stomach with 2mm-3mm silicone tubes together with nasogastric tubes, and intraoperatively, the nasogastric nutrition tubes were placed at about 30cm-40sm in the upper jejunum distal to the anastomosis through the anastomosis.  3, postoperative nutritional management The whole group of cases were kept for 5-7 days after 36h-48h of surgery, when the general condition was good, hemodynamic stability and no serious bleeding tendency, two cases of duodenal stump fistula patients were kept for 20-26 days, one case of anastomotic fistula was kept for more than 40 days, for cases with longer time of tube placement, in addition to the application of Ansol liquid, we also gave our own prepared nutritional solution (milk, broth In addition to the Ansol solution, we also gave our own nutritional solution (milk, broth and other nutritional mixtures). There were no serious adverse reactions in the whole group, but some cases had slight abdominal distension, diarrhea, abdominal pain and other discomfort, which disappeared after adjusting the concentration, drip rate and temperature of the nutrition solution.  Most of the cases had different degrees of weight loss, anemia, decrease in A/G and electrolyte disorders before surgery. 7-10 days after surgery, the weight was maintained or higher than the preoperative level, anemia was corrected, A/G increased or returned to normal, and electrolyte disorders were corrected. All cases in the group recovered better than other concurrent cases, while complications such as anastomotic fistula, poor healing or splitting of the incision were significantly reduced, and clinical treatment costs were lowered.  Discussion In recent years, with advances in surgical, respiratory and circulatory support techniques, perioperative nutritional support for surgical patients has received increasing attention. Many specific nutrients have significant immunomodulatory effects, and nutritional support enriched with these nutrients, especially enteral nutritional support, can be of great importance in enhancing the intestinal mucosal barrier, reducing endotoxin and bacterial translocation, and preventing enterogenic infections and MODS [1 ]. Enteral nutritional support is still a major nutritional approach in modern surgical nutrition therapy [2], and the earlier the start of postoperative enteral nutrition, the earlier the anabolism [3], and enteral nutritional support contributes to the structural and functional integrity of intestinal mucosal cells [4], stimulates digestive secretion, promotes recovery of gastrointestinal function, corrects intestinal mucosal ischemia, reduces enterogenic hypermetabolic response, and reduces the occurrence of complications such as inflammatory response and infection. The main routes of enteral nutrition support are jejunostomy and nasal enteral nutrition tube, which are no longer widely used due to the former complications, and nasal enteral nutrition tube due to its easy and safe placement, comprehensive nutrition, physiological requirements, requirements for monitoring and material conditions, low price and other characteristics [5], and can be left for a longer period of time, for possible complications after gastrectomy, such as anastomotic fistula, duodenal stump fistula The anastomotic edema, postoperative gastric emptying disorder and other complications are an effective safety precaution [6]. In our group, two cases of duodenal stump fistula and one case of anastomotic fistula were healed with longer nasal enteral nutrition tube nutritional support, and the cost of treatment was reduced. Although enteral nutrition support cannot achieve the high calorie and rich amino acid substances of total gastrointestinal nutrition support, with the development and application of total nutrients in recent years, enteral nutrition can obtain a more comprehensive and cheaper nutrition support. Therefore, early enteral nutrition support by nasal intestinal tube after gastrectomy can replace most of total gastrointestinal nutrition and completely replace jejunostomy, which is a safe, low complication, simple, practical and easy to master nutrition support method.