Pathologicaldrunkenness occurs mainly in a very small number of people who have a very low tolerance for alcohol and is a “qualitative abnormality” compared to ordinary drunkenness. Most patients have never drunk alcohol in the past and feel extremely uncomfortable after drinking a small amount of alcohol, but have never had a history of intoxication. Pathological intoxication is an idiosyncratic allergic reaction caused by alcohol, which often occurs after a small amount of alcohol has been consumed and shows a hyperactive rather than a sedative effect. There is often a sudden onset of impaired consciousness, extreme euphoria, aggressive and harmful behavior, and delusions of victimization are also more common. The seizure usually lasts for several hours or a day, and ends after a deep sleep, with no recollection of the seizure after waking up. It is also called “acute alcoholic delusional state syndrome”. It is also reported that it is more appropriately called “atypical or atopic reactive alcoholism”. In any case, the term pathological intoxication is still widely used. Pathological intoxication is a psychotic episode caused by small amounts of alcohol, and most people do not have toxic reactions when drinking this amount. 2. Unlike simple intoxication, patients do not have increased speech, euphoria and obvious toxic neurological symptoms. Patients exhibit environmental and self-consciousness disorders, mostly accompanied by fragmentary horror hallucinations and delusions of victimization, which are characterized by high excitement and extreme nervousness and panic, and patients often suddenly appear aggressive violence under the domination of hallucinations and delusions, such as destroying objects, self-injury or attacking others. The intoxication usually lasts for several minutes, hours or even a whole day, and ends when the patient falls into a sound sleep. 3. The common types of pathological intoxication are hazy and delirious. ① Hazy type: the scope of consciousness is significantly narrowed and narrowed, accompanied by reduced clarity of consciousness and almost complete loss of self-awareness, but there is some connection of inner mental activities, partial perception and reaction to external stimuli, and coordination of inner behavior exists, such as simple greetings, passing obstacles, etc.; more serious impairment of consciousness and orientation, which can be accompanied by delusions, hallucinations and other experiences, often with anxiety and depression, motor excitement with agitated nervousness, purposeless aggression and incomprehensibility; more complete amnesia or insular memory, blunted or absent pupillary light reflex, diminished or absent tendon reflex, etc. Mildly, patients show some vulgar social behaviors repeatedly after drinking certain amount of alcohol. ②Delirium type: Patients exhibit tremors and delirium, complete breakdown of intrinsic mental activity, loss of relevance, intense and disorganized motor excitement, and complete amnesia afterwards. Physiological intoxication, on the other hand, is criminally responsible, because, physiological intoxication can be controlled, and the intoxicated person should foresee or have foreseen the possibility of committing socially dangerous acts after drinking before becoming intoxicated; after becoming intoxicated, the average person does not completely lose the ability to recognize and control. Therefore, for controllable intoxication resulting in crime, generally does not reduce criminal liability.