In the case of hepatitis B ultra-sensitive quantitative >20, patients should follow the doctor’s instructions for drug treatment, general measures, etc., and if necessary, also need to carry out surgical treatment. 1. Drug treatment: usually patients should follow the doctor’s instruction to use nucleotide analogs such as entecavir, lamivudine, adefovir, etc., and also need to use interferon-alpha, polyethylene glycol interferon-alpha and other interferon-like drugs for treatment. 2. General measures: patients usually need to pay more attention to rest, a reasonable combination of diet, appropriate consumption of high-protein, high-vitamin food, and also need to develop good habits, timely cessation of alcohol. For patients with more serious symptoms, they need to take strict bed rest and follow the doctor’s instructions to give a low protein diet. 3. Surgical treatment: Most patients do not need surgical treatment, but if the condition develops to end-stage cirrhosis and liver failure, liver transplantation should be considered. It is recommended that patients should actively cooperate with doctors to carry out systematic treatment when the ultra-sensitive quantitative examination of hepatitis B＞20, so as to avoid delaying the condition, and the drugs should be applied under the guidance of doctors.