Scleroderma in men, also known as Peyronie’s disease, can be effectively managed with treatment to prevent the disease from continuing to progress, but there is no complete cure. Scleroderma in men is a benign progressive disease. The exact pathogenesis is unknown. Some studies suggest that it may be related to autoimmunity, chronic injury, and infectious factors. Continued progression of Peyronie’s disease may be prevented by medication or low-energy shockwave therapy. In some patients, the sclerosis may become smaller and softer with treatment, but will not disappear completely. Serious cases require medication or surgery. Medication is often ineffective, mainly colchicine, verapamil and tamoxifen. Surgical treatments mainly include sponge folding surgery, prosthesis implantation surgery and extracorporeal shock wave. The above medications should be used under medical supervision. If you have sclerosis, you should go to regular hospitals for medical treatment in time and be treated by medication, physical therapy, surgery and so on. Patients usually need to take more rest, avoid fatigue and avoid wearing tight underwear.