Aminotransferases are not always elevated in pancreatic cancer, but may be elevated only when pancreatic cancer leads to biliary obstruction, causing liver cell damage. Transaminases are mainly found in liver cells and their elevated values suggest possible liver damage. Pancreatic cancer, however, does not necessarily cause liver damage, so transaminases are not necessarily elevated in pancreatic cancer. The common bile duct and pancreatic duct open together at the duodenal papilla, so pancreatic cancer occurring at the head of the pancreas may compress the common bile duct, resulting in obstruction of the common bile duct, which may cause liver injury, and so transaminases may be elevated. The main clinical manifestations of pancreatic cancer are persistent and progressively aggravating epigastric pain, loss of appetite, nausea, vomiting, jaundice, and weight loss. It is recommended to consult a doctor in time to clarify the cause of the disease and treat it as soon as possible.