A rheumatoid factor of 60 U/L is relatively minor and is mildly elevated, suggesting possible rheumatoid arthritis (RA). Rheumatoid factor (RF) is a kind of autoantibody with mutated IgG as the target antigen, with a normal value of <20U/L (negative), which is mainly used to diagnose rheumatoid arthritis (RA) and determine its prognosis in the clinic, and the positive rate of RF in patients with RA is 52%～92%. Generally, RF negative patients have milder condition, fewer complications and better therapeutic effect, while positive patients have poor therapeutic effect, often accompanied by complications, such as arteritis and peripheral neuritis, etc. Negative RF or reduced levels can be used as an indicator of remission. RF can also be used as an aid in the diagnosis of other autoimmune diseases. RF positivity can also be seen in systemic lupus erythematosus (SLE), autoimmune hemolytic anemia, dermatomyositis, scleroderma, and pernicious anemia, and dry syndrome. RF can also be positive in some chronic infectious diseases, such as subacute bacterial endocarditis, syphilis, black fever, and tuberculosis. If the rheumatoid factor is elevated to 60U/L, it is recommended to consult the rheumatology and immunology department for further examination under the guidance of the doctor, so that the cause of the disease can be clarified as early as possible and treated in time.