The most common metastatic sites of lung cancer mainly include bone, brain, abdominal cavity and lung, and there are different symptoms depending on the metastatic sites. When bone metastasis occurs, the first symptom is bone pain, and when the metastatic bone is damaged, pathological fracture may occur. 2. When the lesion metastasizes to the brain, it may develop brain occupancy, if this area is responsible for speech, the patient may have problems with speech, if it is responsible for movement, this patient may have problems with movement, and may even develop coma. 3. When a patient has adrenal metastasis, he or she will have abdominal pain, abdominal distension and other symptoms. For example, when the lesion is close to the heart, it may invade the pericardium and cause pericardial effusion, which may lead to heart failure and pericardial tamponade, and when the lesion invades the vena cava, it may cause the obstruction of vena cava reflux, and the patient may have edema of the upper limbs and face. When the lesion invades the trachea, the patient may experience some symptoms of tracheal irritation or blockage, such as blood clotting and coughing; after the blockage of trachea, the patient may experience difficulty in inspiration due to pulmonary atelectasis; when the lesion invades the pleura and causes a large amount of pleural effusion, the patient may experience severe wheezing; in addition, when the lesion directly invades the crest or chest wall, the patient may experience severe pain when the lesion invades this part of the body, these are some typical clinical symptoms of advanced stage lung cancer. These are some typical clinical symptoms of advanced lung cancer.