Myelofibrosis is a diffuse bone marrow fibrous tissue proliferative disease, which is a kind of tumor of hematopoietic system. It is mainly caused by the mutation of genes of hematopoietic stem cells, which leads to the uncontrolled growth of cells in the bone marrow, and the proliferation of bone marrow fibroblasts, which triggers myelofibrosis. From the perspective of traditional Chinese medicine treatment, Chinese medicines can be used to activate blood circulation, remove blood stasis, move qi and relieve pain. According to the clinical diagnosis and treatment, for those with yin deficiency of the liver and kidney, nourishing the liver and kidney, benefiting qi and activating blood can be used, and Nourishing Yin and Activating Blood Soup can be used. For spleen and kidney yang deficiency, warming and tonifying the kidney yang, filling in essence and tonifying blood is the mainstay of treatment, and Nourishing Kidney and Nourishing Blood Soup is used. For those with deficiency of Qi and Blood, tonifying Qi and nourishing Blood should be the mainstay, using Nourishing Qi and Nourishing Blood Tang. For those with Qi stagnation and blood stasis, to promote blood circulation and eliminate blood stasis, and to move Qi to relieve pain, use Activate Blood and Expel Blood Stasis Soup.