Duodenal ulcer is still painful after 6 weeks of medication, you need to choose to continue to take drugs or choose endoscopic and surgical treatment under the guidance of the doctor. Generally speaking, duodenal ulcers can be cured in 4 to 6 weeks after standardized medication, but the specific healing time needs to be based on the patient’s specific situation, for example, if the ulcer area is large, or combined with Helicobacter pylori infection, the healing window will be extended appropriately, so it is necessary to evaluate under the guidance of the doctor to determine whether the medication is effective or not. If it is determined that medical treatment is effective, the duration of medication can be extended appropriately to continue treatment. If the medical treatment is not effective, the medication can be stopped and endoscopic or surgical treatment can be chosen. In addition, duodenal ulcer treatment should be avoided during the stimulation, greasy diet, can be appropriate exercise, stopping and taking medication should be carried out under the guidance of a doctor to avoid adverse consequences.