Stomach pain during sleep is caused by duodenal ulcer, pyloric obstruction, and weakness of the spleen and stomach. Stomach pain that occurs during sleep and is more intense in nature is mostly due to duodenal ulcer. In patients with duodenal ulcer, stomach acid is discharged into the duodenum in a high intensity state due to the absence of food in the stomach to neutralize the stomach acid during sleep, thus causing violation of the duodenal mucosa and inducing a painful feeling in the stomach. In patients with pyloric obstruction, the discharge of food from the stomach is restricted during the disease, and at night, the food consumed in the stomach all day will ferment and rot, which will not only cause stomach pain, but also nausea and vomiting. Many people will have a weak spleen and stomach, and the function of the spleen and stomach is relatively weak, especially when a large amount of food is ingested, which will lead to an increased burden on the spleen and stomach, and a painful feeling in the stomach.