Red pimples on the cheeks are mostly considered as acne, folliculitis or contact dermatitis, etc. They can be controlled by general treatment, localized treatment as well as systemic treatment in order to eliminate the pimples. 1. Acne: local attention to oil control and moisturizing, avoid excessive washing, do not squeeze the lesions with your hands; mild symptoms can be used externally with Vitamin A acid cream, erythromycin ointment, benzoyl peroxide cream or azelaic acid and other preparations; Those who need systemic medication can choose antibiotics such as doxycycline and isotretinoin, and those with serious conditions can also apply glucocorticoids for a short period of time; phototherapy can also be used as well as chemical exfoliators such as salicylic acid agents to assist in the treatment. 2. Folliculitis: should pay attention to skin hygiene and cleanliness as well as to prevent trauma, mainly with local topical drugs such as ichthyolite ointment, iodine tincture or mupirocin ointment treatment, combined with Malassezia infections, need to be combined with anti-fungal sertaconazole and other treatments. 3. Contact dermatitis: should be quickly removed from contact, and avoid re-exposure to allergens, according to the severity of the disease choose antihistamines such as loratadine or glucocorticosteroid treatment, local rubbing zinc oxide cream. For cheek acne more or affect the aesthetic, can consult a doctor, follow the doctor’s instructions on the cause of the symptomatic treatment.