Intestinal epithelial metaplasia refers to the replacement of gastric mucosal epithelial cells by intestinal epithelial cells, i.e., the appearance of epithelial cells in the gastric mucosa that resemble the small intestine or large intestine mucosa, which is a common lesion of the gastric mucosa and is seen in many chronic gastric diseases. It is structurally and functionally different from the gastric epithelium and is divided into small intestine and large intestine types, the latter being prone to malignant changes. Its distribution is very similar to the lesion sites of gastric cancer, and the pathological histology can also see the gradual proliferation of gastric mucosa from intestinal epithelial metaplasia, and even the process of cancer. In fact, intestinalization is an indicator of gastric mucosal damage and an important epithelial change in chronic atrophic gastritis. Intestinalization refers to the replacement of gastric mucosal epithelial cells by intestinal-type epithelial cells, which is a common lesion of gastric mucosa and is seen in many chronic gastric diseases. According to some statistics, enterosis combined with atrophic gastritis accounts for 65.5% of cases, and it increases with age. As the atrophic zone expands, the ratio of enterosis increases. The distribution of intestinalization and atrophic gastritis sites is also basically the same, with the highest rate of appearance in the gastric sinus, followed by the body sinus migration site. Since atrophic gastritis combined with intestinal epithelial metaplasia is closely related to the occurrence of gastric cancer, this situation should be given great attention and should be followed up and reviewed regularly.