The aging of the premenopausal ovaries is a process and not a one-day change. The first manifestation is the absence of ovulation, but the production of estrogen, which is not estrogen but progesterone. The clinical manifestation is often irregular menstruation, i.e. anovulatory functional uterine bleeding. When the endometrium grows thicker and thicker under the influence of estrogen, we need to increase progesterone to make it fall off after maturation, so as to prevent endometrial cancer from developing under long-term stimulation. In terms of treatment, regular use of progestin is hormone compensation therapy, and progestin alone should only be chosen when there is a certain amount of estrogen level in the body. If a person is already menopausal, with complete ovarian failure and lack of both estrogen and progestin, we use both estrogen and progestin at this time. This approach is also divided into two cases. One is for postmenopausal women with a uterus, where it is necessary to add progestin to estrogen use in order to prevent the development of endometrial cancer. Since progestin is used to prevent endometrial cancer, if the patient has had a hysterectomy, there is no problem with the endometrium. In this case we treat with estrogen alone so that the patient can receive the maximum benefit of estrogen for her, and this is the second way. The first method is estrogen plus progestin therapy, in which a certain amount of estrogen and progestin is used every day, 365 days a year, with progestin suppressing the growth of estrogen, a condition we call continuous. In the case of continuous continuous use menstruation does not occur because the endometrium cannot grow because the patient is treated with estrogen plus progestin every day. There is another method called the sequential method, which imitates the process of ovarian secretion, follicular growth and development, and ovulation, with progestin being secreted right after ovulation. This method uses estrogen alone in the first half of the treatment and progestin in the second half. The purpose of using progestin is to allow the endometrium to mature and shed after estrogen stimulation, which means that it is applied in an artificial cycle called sequential. The method used depends on the needs of the patient. For menopausal women in their 40s who wish to have a period, we can use the sequential method, and for postmenopausal women who do not need to have a period, we can use the continuous method. For hysterectomized individuals, estrogen alone is most appropriate.