Lobular hemorrhage under the finger and toe nails is one of the signs of infective endocarditis. Infective endocarditis (IE) is a direct infection by microorganisms (bacteria, fungi and other microorganisms such as viruses, rickettsiae, chlamydia, spirochetes, etc.) that produce inflammation of the heart valves or endocardial wall, including acute and subacute endocarditis. So, how do you differentially diagnose lobar bleeding under the finger or toe nail? The following is a brief introduction: differential diagnosis of subungual bleeding of the finger or toenail: 1, nail visible transverse groove spinning: mucocutaneous lymphnode syndrome (MCLS), also known as Kawasaki disease, is an acute febrile eruption with systemic vasculitis as the main pathological feature MCLS is an acute febrile rash characterized by systemic vasculitis. In the recovery period, the nail can be seen as transverse groove spinning. 2, the tip of the nail has a defect: the tip of the nail has a defect refers to the tip of the nail area showing the symptoms of a defect. 3, thick and brittle nails and many cracks: thick and brittle nails and many cracks is the clinical manifestations of hypothyroidism.