Deep headaches are most often seen in brain abscesses, encephalitis, and brain tumors with external radiation to the ipsilateral side. Deep headache is mainly caused by impaired intracranial blood circulation and cerebrospinal fluid circulation as well as increased intracranial pressure, which stimulates cerebral blood vessels and meninges. Headaches caused by intracranial lesions are more severe, mostly deep distension, blast-like pain, often accompanied by vomiting, signs of neurological damage, convulsions, disorders of consciousness, mental abnormalities and even changes in vital signs in varying degrees. In intracranial tumors, the headache is mostly deep, intermittent and progressively worse, and can be aggravated by stool and coughing, and fundus examination can reveal optic papillary edema. Brain abscesses often come from direct spread of infection in the middle ear, mastoid process, and paranasal sinus, with severe headache, nausea and vomiting, and even impaired consciousness as well as systemic infection symptoms. Inflammatory headache of the meninges usually has an acute onset, with persistent deep headache, accompanied by fever and vomiting. Treatment is based on pain relief and prevention. Lifestyle adjustments are required, such as avoiding alcohol, especially during attacks, quitting smoking, taking steroid medication when traveling, and avoiding foods containing nitrates.