The signs of syphilis recurrence are clinical manifestations and serologic tests. 1. Clinical manifestations: After clinical healing, the chancre appears again, manifesting itself as a painless, itchless, round or oval, well-defined ulcer that rises above the skin surface. Early noma may heal spontaneously. Without timely treatment, a typical rose rash may appear, which in severe cases manifests itself as permanent skin and mucous membrane damage, encroaching on a variety of tissues and organs and even endangering lives. 2. Serological examination: If the titer of anticardiolipin antibody has been lowered and turned negative after treatment, and then the titer rises again after another blood test, this situation requires standardized treatment again. The recurrence of syphilis, you need to go to the hospital in time, under the guidance of the doctor for standardized treatment, according to the course of treatment. After the treatment, we should regularly review, pay attention to personal hygiene, cleanliness, tracking the treatment of sexual partners. Sexual intercourse is strictly prohibited during the treatment period, while the sexual partner also needs to be treated.