Total iron binding capacity is the maximum amount of iron that can be bound by transferrin per liter of serum, and can reflect the level of transferrin. The normal value of total iron binding capacity is generally set at 48-68 μmol/L. The normal range of values varies slightly from hospital to hospital due to the application of reagents and testing instruments. Many clinical liver diseases have the potential to cause a decrease in total iron binding capacity, the most common ones being cirrhosis and primary liver cancer. In particular, current studies have found a close relationship between the value of total iron binding capacity and the progression of hepatocellular carcinoma, and it is possible that total iron binding capacity could be used as one of the monitoring indicators for primary hepatocellular carcinoma. In addition, nephrotic syndrome is also likely to show a decrease in total iron binding level. Iron deficiency anemia and acute hepatitis have the potential to cause elevated values of total iron binding capacity. Some young women and pregnant women themselves may have elevated total iron binding values, but this is not clinically significant at this time and is a normal physiological phenomenon.