Patient: I am the son of a diabetic and would like to ask you some questions. My mother is 58 years old, she suffered from hypertension when she was 45 years old, and got diabetes when she was 55 years old, and when she first got sick, she took metformin, but later she was afraid that it would have side effects on her liver and kidneys. The kidneys have side effects. The doctor at the local hospital said: the ingredients of the health drug is a large number of hypoglycemic drugs, my mother may have eaten too long, not to play a role, it is recommended to inject Novolac insulin, 2 times in the morning and evening, each time 10 units and then according to the blood sugar High and low then adjust, and so on to play a period of time to let the islet cells to restore recovery, in the eating of glucose-lowering drugs to see. I would like to ask now for 3 months to play insulin, blood sugar control in fasting between 4.64-6.25mmol / L, now whether we should change to take hypoglycemic drugs, if change to take hypoglycemic drugs to eat what hypoglycemic effect is good. My mother is 161cm tall and weighs 55kg. She is also taking Enalapril, an antihypertensive drug, and has stable blood pressure control, as well as aspirin and compound salvia drops. I am worried that if I take glucose-lowering drugs again, the burden on my liver and kidneys will not be too heavy, and that if I take these four drugs together, they will not resist each other, so please take a few minutes of your precious time to help me answer, I am grateful. First of all, pure Chinese medicine does not have a clear hypoglycemic effect, as long as the hypoglycemic effect of “Chinese medicine” must contain Western medicine ingredients. Secondly, all hypoglycemic drugs (including insulin) are designed to lower blood glucose, and by lowering blood glucose, the purpose of reducing complications can be achieved, all hypoglycemic drugs (including insulin) are not completely proven to have the effect of reducing complications in addition to lowering blood glucose, only metformin is partially proven to have the effect of reducing macrovascular complications in addition to lowering blood glucose. Therefore, international and national guidelines for the treatment of diabetes have made metformin the drug of choice. The same is true in our country. Third, it is not that insulin treatment is superior to oral medication, and it is not that oral medication damages the liver and kidney. In fact, oral drugs are mainly for poor liver and kidney function is not to eat, but when the liver function is normal, oral drugs cause liver function changes very little. And the application of insulin can also cause many side effects such as weight gain. Therefore, there is no need to switch to insulin when oral medication controls blood sugar very well. However, if oral medication cannot control blood sugar well, you should switch to insulin in time. According to your description of the situation you can switch to oral medication, you can metformin 0.5, three times a day as the basis, plus the use of nandrolone. According to the blood sugar high and low adjust the dosage of nandrolone on it. These drugs and antihypertensive drugs, aspirin will not affect each other.