In the treatment of chronic viral hepatitis B in children, interferon is the main drug, through the correct use of interferon, can achieve more satisfactory therapeutic effect. But in the use of interferon need to pay attention to the following issues: First, pay attention to its scope of application: 1, the child’s age should be at least more than 12 months; 2, before the treatment of children with serum alanine aminotransferase (ALT) and / or alanine grass aminotransferase (AST) with repeated fluctuations or sustained elevation, and ALT elevation of more than the upper limit of the normal value of not more than 10 times; or liver tissue inflammation lesions are more pronounced (inflammation grade in the G2 -G4); 3, although there is no significant elevation of transaminases, but hepatic liver inflammation is not significantly elevated, the liver can be used to treat the symptoms of chronic viral hepatitis. -3, Although there is no significant increase in aminotransferases, but the results of liver puncture pathology suggest that G2S1 or above. 4, serum HBV-DNA level before treatment is more than 5 times 10; no overlapping infections (such as hepatitis C, hepatitis D, etc.); no HIV infection. Second, pay attention to its contraindications for use: 1, infants under 1 year old; 2, serious condition, transaminases more than 10 times the upper limit of the normal value; 3, blood routine suggests that leukocytes are reduced, less than 4.0 × 10 ^ 9 / L, or neutrophils are less than 1.0 × 10 ^ 9 / L. Or platelets are less than 50 × 10 ^ 9 / L; 4, suffering from uncontrolled autoimmune diseases; 5, patients with History of psychiatric disorders, epilepsy, depression, etc.; 6, patients with severe heart disease or other serious illnesses, etc. who cannot tolerate the adverse effects of this drug. 7, those who are using immunosuppressant therapy; interferon products or components of which are allergic; third, pay attention to its side effects: the main 1, the use of influenza-like symptoms such as fever, chills, headache, muscle aches and fatigue, etc.; 2, can be further aggravation of liver function, manifested as transaminase elevation or the emergence of jaundice, etc., such as transaminase elevated more than the upper limit of the normal value of 10 times, the drug should be discontinued in a timely manner; 3, Causes leukopenia and thrombocytopenia: mainly manifested as peripheral blood leukocytes (neutrophils) and thrombocytopenia; if necessary, the drug should also be discontinued to deal with; 4, mental anomalies, there may be depression, paranoia, anxiety and other symptoms; 5, a small portion of the patients with hypothyroidism or hyperthyroidism; other rare adverse reactions are decreased appetite, weight loss. Renal function damage, hair loss and so on. Therefore, when choosing interferon for the treatment of hepatitis B in children, the indications and contraindications for its use should be mastered, and the children should come to the hospital for regular review to prevent side effects from occurring.