The main causes of low differentiated gastric cancer may include genetic factors, H. pylori infection, environmental and dietary factors. 1. Genetic factors: some studies show that about 10% of patients with low differentiated gastric cancer have family history, and the incidence rate can be 2~3 times higher than that of the general population. 2. Helicobacter pylori infection: it has been proved that Helicobacter pylori infection has correlation with many digestive diseases, such as gastritis, peptic ulcer, gastric cancer, etc. Clinically speaking, the risk of gastric low-differentiated carcinoma is significantly higher in the people infected with H. pylori than in those who are not infected with H. pylori. 3. Environmental and dietary factors: the incidence of low-fractionated gastric cancer can also be related to soil and water factors, chemical pollution, etc. In addition, irregular diet, frequent consumption of moldy food, pickled food, etc. are also important risk factors for its incidence. In addition to the above factors, some researchers believe that long-term smoking and drinking, poor mental state and special occupation may also be related to the development of gastric low differentiated cancer. Therefore, in daily life, we should pay attention to maintaining healthy dietary habits, timely treatment of H. pylori infection, quitting smoking and drinking. Regular medical checkups should also be carried out, and timely medical treatment should be sought if there is any discomfort, so as to avoid delaying the condition.