A plus sign for H. pylori indicates a H. pylori infection, and a plus sign represents a H. pylori infection, which generally depends on the patient’s specific situation to determine whether to take medication. Helicobacter pylori is a kind of bacteria parasitized in human stomach, and this kind of bacteria can be transmitted from person to person by mouth or fecal-oral transmission. Infected with Helicobacter pylori can damage gastric mucous membrane and stimulate excessive secretion of gastric acid; it can also weaken the barrier function of gastric mucous membrane and induce gastritis, gastric ulcer and other diseases, and it is also a risk factor for inducing gastric cancer. The normal population test for H. pylori is negative without a plus sign, indicating that there is no infection with H. pylori, if H. pylori a plus sign, indicating that it is positive, representing that it has been infected with H. pylori. The need for treatment should be analyzed according to the specific cause of the disease, and for children, elderly people over 70 years of age, and patients with underlying diseases or contraindications need to be analyzed on a case-by-case basis. For the presence of a plus sign for H. pylori, it is recommended to cooperate with the attending physician’s opinion on whether or not to carry out bactericidal treatment.