With the growth of age, light aging and the influence of gravity, the facial skin will subsequently appear pigmentation, roughness, laxity, sagging, wrinkles and other aging phenomena, hydrafacial injection technology is the use of needles under the control of a micro-computer to adsorb the skin through the negative pressure system, while in the negative pressure of the space of the drug to be injected into the corresponding parts of the treatment method, “micro-needle therapy “is a good way to overcome the barrier effect of the skin stratum corneum on the transdermal absorption of drugs, but also an important means of improving the absorption of drugs in the skin wound, so the combination of the two methods of facial rejuvenation, can produce the effect of 1 + 1 is greater than 2? I. Subjects 50 cases were selected from my hospital, of which 2 cases were male and 48 cases were female. The age distribution is from 35 to 55 years old, with an average of 42 years old. The grouping was based on the following: 25 cases in the treatment group, 24 females and 1 male, with a minimum age of 35 years old and a maximum age of 55 years old. In the control group, there were 25 cases, 24 females, 1 male, the minimum age was 35 years old and the maximum age was 54 years old. Exclusion criteria: ① people who have received facial treatment within 2 months; ② people who have done related skin care within 1 month to influence the judgment of the results; ③ pregnant or lactating women; ④ psychiatric patients, alcoholics, drug addicts; ⑤ patients with systemic diseases or serious skin diseases; ⑥ people with a history of severe skin allergies; ⑦ people who have not received treatment in accordance with the provisions of the treatment, and it is impossible to judge the effectiveness of the treatment. Second, the choice of medical instrument Hydrographic needle injector, roller micro-needle, non-crosslinked hyaluronic acid, armored medical skin care products. Preparation for the test The room temperature is controlled to be 26℃. The tester enters the test environment 20 minutes in advance, cleanses the face and wipes away the excess water and stands still for 10 minutes. Frontal view position, left side position, right side position, three-position use of the skin tester for testing. The main detection of facial skin wrinkles, texture, pores, pigmentation, capillary dilatation, purple. The percentile values obtained after analysis by the instrument were used for statistical purposes, and the higher the value, the better the degree of improvement. At the same time, nursing staff in the same angle, the same light source on the front of the face, the left side of 45 degrees, the left side of 90 degrees, the right side of 45 degrees, the right side of 90 degrees of the face to take pictures and records for archives. Treatment process Treatment group: three treatments for a course of treatment, each interval of 1 month, each treatment will be a combination of hydrafacial injection and microneedle introduction. Control group: three treatments for a course of treatment, each interval of 1 month, each time only the injection of hydrafacial injection treatment, other postoperative procedures are the same. Before treatment, facial skin is cleaned, photos are taken, preoperative communication is made, and anesthesia is applied. Candidates applying anesthesia at the same time the doctor for instrument debugging: needle length, amount of medicine, mode, negative pressure. Remove the anesthesia, complete sterilization. The order of treatment follows bilateral cheeks – bilateral temples – jawline – forehead – nose, nose – eye area. Surface ooze was gently wiped with saline afterwards. Microneedle introduction: A 0.5mm microneedle roller is used to draw the dissolved solution and essence together in a 10ml syringe and placed in a sterile curved tray. Microneedle roller operation is carried out by zones, and the treatment around the eyes should not be done with brute force, and the introduction should be carried out gently and superficially. After the introduction of microneedle roller, the solution is evenly applied to the surface of the skin, allowing it to be completely absorbed. After the operation, apply the refrigerated transparent collagen crystal protein mask, together with the red light irradiation for 15 minutes and the mask for 40 minutes. Refrigerated mechanical size of the mask can effectively sedate the pain, red light irradiation can be very good to help repair the redness, improve the satisfaction of the treatment after surgery, shorten the repair time; Post-operative precautions: 6 hours after the operation can be used after sterile distilled water will be the face of the exudate and dust cleaned off, 24 hours can be used externally to repair the skin sprays or essences, every interval of 8 hours can be used externally to apply a piece of mechanical size of the aseptic restoration of the mask, 48 hours! Within 48 hours to do a good job of repair, hydration, sun protection. Avoid spicy stimulation and alcohol, avoid high temperature sauna and bath. One month later, review for the next treatment. V. Treatment results All 50 patients completed 3 treatments. Combined with the skin testing instrument to judge the spots, wrinkles, skin texture and pores of the four evaluations, and a comprehensive evaluation of the candidate’s own satisfaction (divided into ABCDE five levels). In the treatment group, there were 24 cases with improvement of 50%-74% or more as judged by the skin testing instrument, and the effective rate was 96%. In the treatment group, there were 24 cases with improvement of 50% – 74% or more as judged by the skin testing instrument, and the effective rate was 96%. 24 cases were graded A, 1 case was graded B, 18 cases were graded C, 5 cases were graded D, and 1 case was graded E. In the control group, there were 18 cases with improvement of 50%-74% or more as judged by the skin testing instrument, 1 case of grade A, 6 cases of grade B, 17 cases of grade C, 1 case of grade D, and 0 case of grade E in the evaluation of the candidates themselves, and the comprehensive effective rate was 72%. Patients believed that the combined treatment skin texture significantly improved, and the recovery period after treatment was short and recovery was faster. This treatment is more obvious for the improvement of patients’ skin aging such as pigmentation, wrinkles, skin texture, enlarged pores and other skin aging, and the satisfaction is higher; VI.Conclusion This time, we used the combined treatment of hydrafacial injection and microneedle introduction to observe the improvement effect on skin rejuvenation. All 25 patients in this treatment group got different degrees of improvement in the treatment process, without obvious side effects. The dermal skin was targeted for drug delivery through hydrafacial injection, and then the epidermal layer was activated and stimulated by cells through micro-needle roller, which further helped the penetration and absorption of the drug to achieve the effect of facial rejuvenation. In this study, we observed the role of hydrafacial injection combined with microneedle introduction in facial rejuvenation, and from the experimental results, the method is safe, without side effects, and provides a new method of combined treatment for facial rejuvenation. Tips: The aging of the skin will show different symptoms as people age, and the anti-aging of the skin is also a project that people are constantly pioneering research, and nowadays many beauty seekers want to achieve the effect of making the skin beautiful in a simple, safe and effective way. However, for the improvement of overall skin texture and anti-aging, there are certain limitations of single injection. Hydrafacial injection technology is under the control of a micro-computer utilizing a special injection tool to suction up the skin through a negative pressure system, while injecting the medication to be injected into the appropriate area in the space of the negative pressure. Microneedle therapy is the use of many tiny needles on the positioning needle to stimulate the skin, in a very short period of time the microneedle can make more than 200,000 microfine pipelines, positioning, stratification, quantitative skin care active ingredients or nutrients directly into the subcutaneous tissues, a variety of nutrients active ingredients are rapidly absorbed by the skin tissues to play a role in order to produce results.