Lung cancer is the most common respiratory tumor and can invade the pleura, ribs, mediastinum and metastasize to the skull, which can cause pain in multiple locations throughout the body. The most common locations of pain are the thoracic and lumbar spine. Lung cancer can invade the pleura, invade the nerves and invade the mediastinum, so it causes pain. Metastasis to the abdomen and liver can cause pain in the abdomen, metastasis to the kidney and lumbar spine can cause pain in the lower back, and metastasis to the skull can cause headache. Thus, lung cancer is a disease that can metastasize in multiple places throughout the body, and attention should be paid to the management of pain in the process of clinical treatment.