Acute liver failure is a life-threatening disease that can lead to multiple organ failure and eventual death. When not effectively treated, death may occur within a few days. 1. Liver failure can lead to severe hepatic encephalopathy with varying degrees of severity of drowsiness, personality changes, cognitive impairment, confusion, excitement and deep coma. The higher the grade of hepatic encephalopathy, the worse the prognosis. It leads to brain edema as well as intracranial hypertension and other diseases, and finally death. 2. Hepatic failure can occur with insufficient synthesis of coagulation factors, causing spontaneous bleeding in the body, and hemorrhagic shock. This kind of hemorrhagic shock is difficult to correct, and even if cold precipitation rich in clotting factors is transfused, the bleeding cannot be stopped easily due to excessive consumption, which eventually leads to death. The function of polymorphonuclear leukocytes is impaired, reducing their phagocytic and regulatory effects. This leads to a dramatic decrease in the body’s immune function, which is highly susceptible to infection, infectious shock causing hemodynamic instability and death. 3. Liver failure can also present with hyponatremia, hypokalemia, hypophosphatemia and acid-base imbalance, such as respiratory acidosis. These electrolyte abnormalities may lead to cardiac arrhythmias that can cause death. After liver failure, active treatment is needed, but of course there are many causes of liver failure, including cirrhosis, drug-related liver injury, liver tumors, viral hepatitis, etc. Some diseases can be treated by liver transplantation, enough to obtain a better prognosis, otherwise the mortality rate is very high.