Carotid atherosclerosis is a large plaque. If carotid atherosclerosis with plaque is relatively mild or asymptomatic, conservative treatment is needed. Conservative treatment is mainly to slow down the progress of atherosclerosis, and aspirin and statin can be used to regulate lipids. In case of hypertension, hyperlipidemia, hyperglycemia, these conditions should be treated reasonably and effectively, keep a good mood, maintain good habits, and eat foods with low salt, low fat, and coarse fiber, which will help stop the progress of atherosclerosis. In addition, if there is severe narrowing of the arteries and some symptoms are produced, surgical intervention is needed, which is divided into minimally invasive surgery and open surgery. In short, it is to remove the plaque or open the occluded or narrowed blood vessels, which will help to relieve the symptoms. However, lifestyle changes and medication are lifelong and must be adhered to in order to prevent the progression of atherosclerosis.