Pregnancy after drinking alcohol may result in abnormal embryonic development, arrest of development, miscarriage, low birth weight babies, mental retardation, malformations such as scoliosis, spina bifida, anencephaly, and other adverse effects. The risk of teratogenicity during pregnancy is relatively high with long-term intake of large amounts of alcohol, especially in the first trimester, which is an important period for the growth and development of various organs and tissues of the fetus and is susceptible to internal and external adverse effects. We should pay close attention to the hormone levels and developmental indicators in the body to understand whether the embryo is developing well in the uterus. We should conduct prenatal screening for Down’s syndrome between 11 and 13 weeks of pregnancy, and do ultrasound to measure NT value and blood tests for alpha-fetoprotein, free estradiol and chorionic gonadotropin to detect fetal neural tube defects, congenital dysmorphism and other abnormalities.