Exfoliative Keratolysis can be treated with oral medications, and topical medications. Exfoliative Keratolysis is a seasonally related skin condition that is a superficial exfoliation of the stratum corneum of the palmoplantar region. Oral medication and topical medication are available. 1. Oral medication: methylcobalamin tablets, roxithromycin capsules, compound glycyrrhizin tablets, olopatadine hydrochloride tablets, etc. can be used. 2. Topical medications: If the patient’s symptoms are more serious, they can also be applied by using tacrolimus ointment, dieldrin cream, glucocorticoid preparation ointment, such as mometasone furoate gel, hydrocortisone butyrate cream. Patients with exfoliative keratolysis should pay attention to skin protection, which can reduce the symptoms of dry skin on hands and feet. In addition, patients can eat a diet rich in vitamin A foods, such as tomatoes, carrots, liver, egg yolks and so on. If patients with exfoliative keratolysis need to use drugs, it is recommended to follow the doctor’s instructions.