Chickenpox is caused by varicella-zoster virus infection of the organism. The varicella-zoster virus is transmitted by droplets, patient’s blister fluid, etc. It first invades the mucous membranes of the upper respiratory tract of the organism, proliferates locally and forms the first toxemia. The virus then replicates in the reticuloendothelial system and causes a second toxemia. The virus can spread to the keratinocytes of the epidermis and the epithelial cells of the mucous membranes, causing vacuolar degeneration of the cells and the formation of blisters. Chickenpox initially appears as a reddish blotchy rash or papule, and then develops into blisters and pustules as the disease progresses. At the same time, it may be accompanied by systemic symptoms such as fever, headache and fatigue. If there is any discomfort, it is recommended to consult a doctor in time for diagnosis and treatment.