Strictly speaking, drugs do not directly lead to heart failure, usually improper use of drugs induced by the aggravation of heart failure. Heart failure refers to a decline in the pumping function of the heart due to various reasons, and the amount of blood ejected from the heart cannot meet the needs of normal metabolism of the organism, and the main clinical symptoms include dyspnea, activity limitation and edema. The causes of heart failure include myocardial lesions, such as coronary heart disease, myocardial infarction, myocarditis, dilated cardiomyopathy, hypertrophic cardiomyopathy, as well as diabetes mellitus, hyperthyroidism, connective tissue disease and other causes of myocardial lesions. There are also diseases that cause overloading of the heart such as hypertension, pulmonary hypertension, aortic stenosis, pre-coronary artery disease, chronic anemia, and so on. In the stable phase of heart failure, the patient is less symptomatic and may have only limited activity, but a variety of factors can precipitate an acute exacerbation of heart failure. The ones related to the use of medication include large amounts of fluid intake or inappropriate discontinuation of diuretics, which increase blood volume and worsen the preload of the heart; inappropriate use of antihypertensive medication or discontinuation of medication, which leads to poor control of blood pressure, and excessively high blood pressure increases the afterload of the heart. There is also the acute stage of heart failure, the use of B-blockers is not recommended, because it weakens myocardial contractility and worsens the symptoms of acute heart failure. Therefore, when a patient has heart failure, care must be taken to avoid the various factors that trigger the aggravation of heart failure, so as to avoid adverse consequences.