The first step is to relax and remove triggers such as infections, food and medications, especially for physical urticaria, to reduce hot and cold stimulation and scratching. Even if no trigger is found, the condition can be controlled by medication. (1) Antihistamines: first-generation antihistamines (cycloheximide, chlorpheniramine, deslorpromazine, etc.) and second-generation antihistamines (such as cetirizine, imipramine, epinastine, loratadine, etc.). It is worth noting that the first generation antihistamines have strong side effects of drowsiness and should not be taken for driving or working at height. The second generation antihistamines have less drowsy side effects, but some women are more sensitive and have more pronounced drowsy side effects. For chronic urticaria patients should follow the doctor’s instructions to take medication daily, a period of time after the rash is controlled, and then slowly reduce the medication, rather than intermittent medication according to their own itching or not or stop the medication, which can not effectively control the disease, but also may make the disease prolonged. (2) Glucocorticoids: For chronic urticaria patients generally do not use hormone therapy, only for severe, especially acute urticaria with systemic symptoms, glucocorticoids are applied intravenously or orally, but should avoid long-term application. (3) Vitamin C, calcium and other drugs that reduce vascular permeability. (4) Traditional Chinese medicine. Warm tip: please combine the specific medication with clinical, by the doctor face-to-face guidance shall prevail.