Hidden pain in the middle of the epigastrium may be caused by cardiovascular disease, gastric disease, pancreatic disease and so on. 1. Cardiovascular diseases: such as myocardial infarction, the patient may have severe retrosternal pain, the pain may radiate to the abdomen, so that the patient appears to have epigastric pain in the middle of the epigastric region. 2. Gastric diseases: such as gastritis, gastric ulcer, duodenal ulcer, etc., will affect the digestion and emptying of food, if the food is in the stomach for a long time, it will cause irritation to the lesion area, thus causing hidden pain in the middle of the upper abdomen. 3. Pancreatic disease: If the patient has irregular life and overeating and other bad habits, it may induce pancreatitis, which will lead to the patient to appear epigastric pain in the middle, the patient may also have nausea, vomiting and other symptoms. The pain in the center of the upper abdomen may also be caused by cholelithiasis. If the pain is not relieved by rest, it is recommended to consult a doctor, under the guidance of the doctor, complete the relevant examinations to determine the cause of the disease and treatment.