Treatment of chronic obstructive pulmonary disease in exacerbation: 1. Determine whether the cause of acute exacerbation is bacterial infection or viral infection. 2. Use bronchodilators, either salbutamol or ipratropium bromide, and let patients inhale through a small nebulizer to relieve symptoms. 3. Inhale oxygen at low flow rate, usually at 28%-30%, to avoid carbon dioxide retention caused by high concentration of inhaled oxygen. 4, If the patient has dyspnea, cough with sputum, increased sputum volume and purulent fluid secretion, penicillin drugs or cephalosporins can be used.5. Glucocorticoids can be used.6. Use expectorants, such as bromohexine and aminoglutethimide. If the patient has respiratory failure, a non-invasive ventilator or an invasive ventilator can be used.