Toenail detachment after chemotherapy for breast cancer can be treated with suspension of chemotherapy, local disinfection, good dietary management, and antibiotics or albumin infusion if necessary. Toenail loss after chemotherapy for breast cancer is mostly due to the side effects caused by chemotherapy drugs, therefore, it is usually necessary to suspend chemotherapy, and apply iodine povidone to disinfect the local tissues at the place where nails fall off. At the same time, breast cancer patients are advised to eat more vitamin and protein-rich foods, such as fresh vegetables and fruits, fish soup, lean meat porridge, etc., which is conducive to the growth of new nails. For breast cancer patients with infected nails, oral or intravenous antibiotics should be given for anti-inflammatory treatment, and some patients also need to enter albumin and other drugs to strengthen nutrition, enhance the body’s resistance and reduce the incidence of infection.