A very itchy face with mupirocin application may be considered as an allergy to the anti-inflammatory component of mupirocin or an allergic reaction to the matrix component of its drug. In clinical treatment, anti-allergic treatment can be administered. If the rash is more severe and red and swollen, intramuscular injection of compound betamethasone injection is required to enhance immunosuppressive, anti-inflammatory and anti-allergic treatment. At the same time, compound glycyrrhizic acid monoammonium S sodium chloride injection should be ordered for anti-allergic and immunomodulatory treatment. In terms of antihistamine drug selection, Olopatadine hydrochloride tablets and fexofenadine hydrochloride tablets can be applied. Along with intensive anti-allergy treatment, topical application of zinc oxide ointment of boric acid and black bean distillate oil can be applied. Avoid makeup and sun exposure during the treatment period.