HPV virus CIN grade 3, for HPV virus CIN grade III, is a precancerous lesion of the cervix, if it continues to develop it will become cervical cancer, so it is more serious and needs timely treatment. CINIII is cervical intraepithelial neoplasia grade 3, which is a precancerous lesion close to cervical cancer, but not cervical cancer, and it is possible to be cured by timely treatment. Therefore, cervical intraepithelial neoplasia CINIII is not serious, but it should not be ignored and needs timely treatment. In general, cervical intraepithelial neoplasia CINIII requires cervical conization, the nature of which is determined by postoperative pathology. If no infiltration is found in postoperative pathology, hysterectomy is not necessary and only regular review is needed. However, if micro-invasive carcinoma is found in postoperative pathology, total hysterectomy can be performed according to medical advice. Meanwhile, patients should establish positive emotions, avoid unnecessary mental pressure, cooperate with diagnosis and treatment under normal psychological state, and exercise strong will, which is also conducive to the recovery of the disease. If diagnosed with HPV CINIII, it is recommended to carry out standardized treatment as soon as possible to reduce the adverse effects of the disease.