Uremia is a clinical syndrome in which the body is unable to produce urine through the kidneys to excrete the waste and excess water produced by metabolism from the body, causing a range of symptoms. Uremia is the ultimate end of progressive deterioration of kidney disease. When most of the kidneys are damaged by fibrosis, excessive accumulation of creatinine, uric acid, urea, β2 microglobulin, guanidine, amines and other substances in the body causes toxic effects in the digestive tract, heart, lungs, nerves, muscles, blood, skin and other systems of the body, leading to widespread systemic toxicity, resulting in the development of uremia. With the occurrence of uremia, patients with kidney disease will experience nausea and vomiting, lack of food and drink, low urine, high blood pressure, itchy skin, breathing difficulties and other symptoms, and in serious cases, complications of heart, brain, nerve and other multi-organ complications, coma, shock and other serious symptoms, threatening the lives of patients. How does uremia occur? Uremia can develop from chronic kidney disease, or secondary to diabetes, hypertension, or lupus erythematosus. Some people with uremia have never had a diagnosis of kidney disease before being diagnosed, and no obvious symptoms of kidney disease have occurred, so it is wrong to think that the occurrence of uremia is as straightforward as the occurrence of the flu. In fact, uremia appears because long-term kidney disease is already growing and the kidneys of uremic patients have been unknowingly damaged. Only, these uremic patients do not have any outward manifestations, even if they have minor conditions such as loss of appetite, weakness, foam in the urine, more frequent visits to the toilet at night, etc., they either do not take it to heart or place these symptoms on other diseases. It is this misconception and lack of awareness of UTI that makes these people delay the treatment of kidney disease, allowing it to continue to deteriorate and progress, and eventually evolve into uremia.