Various causes of renal structural and functional disorders make the kidneys unable to excrete the waste and excess water produced by metabolism in the body, thus causing edema, hypertension, anemia, metabolic acidosis, hyperkalemia, and the end stage of impaired function of multiple organs to become uremic syndrome. the following conditions can be the cause of uremia. 1, various primary glomerulonephritis, such as lgA nephritis, membrane proliferative nephritis, acute nephritis, membranous nephritis, etc. 2, secondary to systemic diseases, such as systemic lupus erythematosus, allergic purpura, diabetes mellitus, hyperuricemia, long-term hypertension, etc. 3, chronic inflammatory infections resulting in decreased renal function, such as chronic pyelonephritis, renal tuberculosis, etc. 4, urinary system stones, strictures and obstructions, etc.: such as kidney stones, bilateral ureteral stones, urethral strictures, prostatic hyperplasia, urethral tumors, pelvic tumors involving the ureter, etc. The first cause of uremia is chronic nephritis, the second cause is diabetic nephropathy, and the third cause is hypertensive kidney damage. However, with the increase in the incidence of diabetes, it has gradually replaced chronic nephritis as the first cause of uremia.