There are many causes of uremia, which is the end stage of chronic kidney failure, and the final development of all kidney diseases is uremia. The most common causes are diabetic nephropathy, which can involve the kidneys after suffering from diabetes for a long time and appear as diabetic nephropathy. Diabetic nephropathy will gradually affect kidney function and develop kidney malfunction, such as kidney failure, making patients slowly develop uremic syndrome. High blood pressure will affect the glomerular arteries, making the kidney arteriosclerosis, resulting in insufficient blood supply to the kidneys, the gradual atrophy of the kidneys, the gradual increase in blood creatinine, the symptoms of failure, the end stage will become uremic syndrome. There are many kinds of common glomerulonephritis, including primary and secondary glomerulonephritis. Interstitial kidney disease or chronic interstitial nephritis in the absence of good control will eventually develop over the years with varying degrees of kidney function impairment, after which patients will develop uremia. There are many other obstructive causes, men with prostatic hyperplasia, abdominal tumors compressing the renal ureter, malignant tumors directly invading the kidney, and these patients can develop uremia. Renal vascular diseases, such as renal artery stenosis can also cause renal ischemia, and finally patients will develop renal fibrosis and gradual atrophy, and renal function will be gradually lost, and the final outcome is also uremia. So there are many causes of uremia, not only kidney diseases, but also diseases of other systems. Hypertension is a cardiology disease, diabetes is an endocrinology disease, respiratory disease such as pulmonary hemorrhage-nephritis syndrome, and immune system disease lupus nephritis will eventually affect the kidneys, along with the gradual increase in creatinine, which can lead to uremia if not properly controlled. The current proportion of antibiotic use is relatively high, the rate of abuse is relatively high, long-term use after months and months also prone to cause kidney function problems. The main impact of antibiotics is to cause interstitial kidney damage, such as gentamicin and other drugs have basically been eliminated, because the nephrotoxicity is too large. So the formation of uremia stems from the awareness and control of the daily disease, patients to avoid the occurrence of uremia, any disease should be standardized treatment, rather than self-treatment, or go to the clinic with random drug treatment. Patients must always keep a clear head, be aware of the disease, and drugs must be used under the guidance of a doctor. People who buy drugs on their own had better read the instructions carefully, some drugs do damage the kidneys and often do not pay attention to, think that the drug dose is too small directly increase the dose are possible uremic syndrome.