Progesterone local vaginal plug is better than injections. The administration of progesterone through vaginal plug is conducive to better absorption of progesterone and better relief of low progesterone, and the use of progesterone capsules through vaginal plug relieves pain, hardness and allergy caused by intramuscular injection. The use of progesterone in early pregnancy is mainly to preserve the fetus, through vaginal administration can be given at home by itself, reducing the amount of activity of the pregnant woman, which is conducive to better preservation of the fetus. How early pregnancy progesterone deficiency is more, need vaginal administration with intramuscular injection at the same time, if through a variety of ways to be able to replenish the lack of movement in the body, it is recommended to choose the vaginal administration of progesterone for administration. During the use of progesterone suppositories, attention should be paid to maintaining personal hygiene, changing underwear regularly, keeping the vulva clean and dry to avoid inducing vulvar itching.