The reference value of immunoglobulin E is 0.1-0.9 mg/L. Simple elevation is seen in IgE multiple myeloma, in atopic reactive diseases bronchial asthma, allergic rhinitis, atopic reactive rhinitis, allergic bronchopulmonary aspergillosis. Then there are parasitic infections, T-cell insufficiency, other soft tissue eosinophilic granulomatosis; its reduction is seen in multiple myeloma, rheumatoid arthritis, and gamma globulin-less disease; also chronic paranasal sinus tumors, sarcoidosis, chronic lymphocytic leukemia; and silicosis and asbestosis.