High immunoglobulin A is caused by an autoimmune imbalance. High immunoglobulin A occurs in common diseases such as hepatic insufficiency, hepatic decompensation, or the development of chronic liver hyperplasia, as well as cirrhosis of the liver. In addition, when immunoglobulin A is high, it also indicates the presence of immune diseases such as rheumatism, rheumatoid arthritis, liver syndrome, or systemic lupus erythematosus, which can cause some changes in immunoglobulin. Finally, high immunoglobulin A can also occur in the presence of skin diseases, such as acute eczema and acute urticaria, which can also have the above clinical symptoms and changes.