Fetal abortion, spontaneous miscarriage, and embryo biochemistry are all pregnancy loss, where an embryo forms and lays but does not continue to develop healthily, which may be related to the mother, the embryo or fetus, and the sperm. The following is a brief discussion of the relationship between pregnancy loss and sperm. 1. Sperm vitality and morphology: Sperm vitality and morphology are routine items in semen examination, which mainly affect the fertilization process and are important references for choosing the fertilization method, especially in patients with primary infertility where weak teratozoospermia can significantly affect the fertilization rate and clinical pregnancy rate in IVF cycles. At the same time, studies have shown the presence of lower sperm forward motility and higher malformation rate in couples with recurrent miscarriage. 2. High sperm DNA fragmentation index (DFI): Sperm DNA fragmentation index (DFI) is not a conventional indicator of semen examination. Recent studies have shown that sperm DFI is an important factor in pregnancy loss. Couples with recurrent miscarriage have a high sperm DFI, however, it is controversial whether sperm DFI can predict pregnancy outcome. 3. Sperm chromosomal abnormalities: When the male partner has an abnormal karyotype of his own, some of the sperm produced may be abnormal. In contrast, when the male partner has a normal karyotype, he may also have sperm with chromosomal abnormalities due to pathological factors that interfere with the sperm formation process. These abnormal sperm and eggs have a high chance of miscarriage even if the baby is conceived, making it difficult to preserve the pregnancy. Studies have shown that couples with recurrent miscarriages have increased aneuploidy of sperm chromosomes. Sperm abnormalities may be accompanied by underlying diseases of the male partner, such as varicocele, obesity, infectious factors, and unhealthy lifestyle are all factors that can affect sperm quality such as staying up late, smoking, and alcohol abuse. It may require varicocele treatment, anti-oxidative stress treatment, micronutrient supplementation, Chinese herbal medicine for physical conditioning, smoking and alcohol cessation, exercise, weight loss, etc. In conclusion, both husband and wife should work together to welcome the arrival of a healthy baby together.