Herpes in the corners of the mouth is commonly known as herpes simplex and herpes zoster, and the symptoms vary from disease to disease. 1. Herpes simplex (1) primary herpes simplex: primary herpes simplex will start with skin pain, mainly tenderness and burning pain, in addition to systemic symptoms, such as fatigue, poor appetite, fever, lymph node swelling and pain, etc., with the development of the disease will gradually appear blisters, blisters rupture after the vesicles, and then the skin lesions gradually recover. (2) recurrent herpes simplex: recurrent herpes simplex usually does not have systemic symptoms, compared with the initial type of herpes simplex symptoms are relatively mild, will appear in the corner of the mouth a small number of blisters, blisters are generally smaller, and the duration of a shorter period of time. 2. Herpes zoster: herpes at the corners of the mouth, the surrounding skin has burning or burning, the skin’s sensation will become more sensitive, it is easy to produce a sense of tenderness, herpes is usually a cluster distribution, not fusion, the wall of the blisters is tense and shiny, herpes fluid is clarified, there is a reddish halo around the periphery, and is accompanied by neuralgia. Herpes at the corners of the mouth should be taken seriously, go to the hospital in a timely manner, identify the cause and then treat the symptoms.