Feeling tired and fatigue in both legs may be caused by muscle strain, lumbar disc herniation compressing nerves, spinal cervical spondylosis, cerebrovascular disease, lower limb vein thrombosis, lower limb varicose veins, etc. The two legs feel very tired, very tired situation, need to be combined with specific physical analysis, simple exercise fatigue and mild lumbar disc herniation after rest can mostly be relieved, if the symptoms do not ease or even aggravate, need to go to the hospital to clarify the cause of active treatment. 1, muscle strain: when after strenuous exercise or physical labor, calf muscle subtle injury produced by aseptic inflammation, resulting in two legs Feel very tired and exhausted. This situation can be localized using warm towels hot compress affected limbs. Infrared physiotherapy can also be used, and can generally be relieved after rest, without the need for special medication; 2, lumbar disc herniation compression nerve: mostly occurs in long-term physical labor or sedentary people. Due to the protrusion of the nucleus pulposus from the lumbar intervertebral disc, compression of the spinal cord causes pain and numbness in the lower extremities, and there may also be two legs feel very tired, very tired, accompanied by lumbar spinal stenosis patients will not be able to walk for a long time. In this case, it is necessary to go to the hospital for lumbar disc CT and lumbar MRI examinations to clarify the degree of protrusion and segmentation. Mild cases can take nerve-nourishing drugs, such as methylcobalamin tablets, etc. Patients with severe lumbar disc herniation combined with spinal stenosis need surgery to remove the herniated nucleus pulposus; 3. Spinal cord type cervical spondylosis: due to the herniated cervical spine compressing the nerves in the neck causing abnormal movement and sensation in the lower extremities, resulting in both legs feeling very tired and exhausted, and the diagnosis can be confirmed by combining with cervical MRI. In mild cases, drugs such as methylcobalamin tablets can be taken orally to nourish the nerves and relieve neuroedema. If necessary, a cervical brace can be worn, and in severe cases, surgery is required. 4. Cerebrovascular disease: Patients with cerebral infarction or cerebral hemorrhage have symptoms related to brain tissue ischemia and central nerve compression causing both legs to feel very tired and fatigued. This condition requires examination of head CT, head MRI and other exclusion, active treatment of the original disease, such as cerebral infarction patients actively use urokinase, streptokinase and other drugs for thrombolytic therapy. Patients with cerebral hemorrhage use aminocaproic acid, tranexamic acid and other drugs for hemostatic treatment; 5. Lower limb venous thrombosis: people who are bedridden for a long time and have poor blood circulation in the lower limbs are prone to lower limb venous thrombosis, with symptoms of swelling and pain in the lower limbs, as well as both legs feeling tired and fatigued, which can be diagnosed by arteriovenous ultrasound of the lower limbs. Mild patients can be anticoagulated, such as subcutaneous injection of low-molecular heparin, etc. Patients with unstable thrombosis are better off with inferior vena cava filter implantation to avoid pulmonary embolism; 6, varicose veins of lower limbs: due to long-term standing, lack of activity of lower limbs and other factors, can lead to varicose veins of lower limbs, two legs feel very tired, very tired. This condition can be treated with compression therapy using elastic stockings and if necessary, surgery for varicose veins. There are more causes of both legs feeling very tired and tired, and the fatigue of lower limbs caused by exertion can mostly be relieved after rest, while other diseases need to go to the hospital for systematic treatment.