Hepatitis B 145 positive refers to positive hepatitis B surface antigen, positive hepatitis B e antibody and positive hepatitis B core antibody, three positive indicates a small triplet of hepatitis B virus. Small triple-positive virus replication is not active, whether it is infectious and whether it needs treatment need to be combined with the level of liver function test and the level of HBV-DNA of hepatitis B virus. If the liver function is abnormal and the quantification of HBV-DNA of hepatitis B virus is higher than 10^5, it means that it is infectious and needs anti-hepatitis B virus treatment. The main choice of drugs for anti-hepatitis B virus treatment are first-line drugs such as pegylated interferon alpha-2b or pegylated interferon alpha-2a, or oral first-line drugs with entecavir and tenofovir, but they need to be administered under the supervision of a doctor.