Chest pain after staying up all night belongs to the local tissue condition abnormality, cause the corresponding lesion causes mainly include coronary heart disease, herpes zoster, pleurisy, intercostal neuralgia and so on. 1. Coronary heart disease: coronary atherosclerosis, after staying up all night may lead to vasospasm, causing ischemic symptoms to worsen, further leading to the production of corresponding symptoms. 2. Herpes zoster: after staying up late, the body’s immune system decreases, which may induce viral infections, further leading to herpes zoster, damage to the nerves causing the corresponding symptoms. 3. Pleurisy: Infection further leads to inflammation of the pleura, which can also cause related symptoms. 4. Intercostal neuralgia: correlates with decreased immunity and infections, and abnormalities in the intercostal nerves can cause corresponding symptoms. After staying up all night with a vague pain in the chest, the symptoms continue to worsen, you need to consult a doctor in time to observe, diagnose the cause of the disease, and then standardize the treatment under the guidance of the clinician.